image image image image
Cardiovascular Imaging Lab CICL offers cutting edge echocardiographic and vascular imaging to support and enhance human studies conducted within the NUHS. We establish and oversee compliance with imaging protocol guidelines. Read the Full Story
Pharmacokinetic Lab The mission of the Pharmacokinetic and Pharmacodynamic (PK/PD) Analytical Laboratory is to provide quality bioanalytical service, to quantify the active drug and/or its metabolite(s) in different biological matrices. Read the Full Story
Biostatistics Unit The Clinical Biostatistics and Pharmacometric Unit of IMU is a one-stop centre that provides data management, biostatistical and computing capabilities to support high quality clinical trials or studies from conception through to completion. Read the Full Story
Genomics Core Laboratory The Genomics Core Laboratory supports activities critical for experimental therapeutics and investigational medicine. It offers state of the art equipment for analysis of DNA, RNA and protein-based biomarkers in body fluids, frozen/archival tissues, and culture and environment isolates. Read the Full Story

PK/PD Analytical Laboratory


Genomics Core Laboratory


Clinical Pharmacology Group


Clinical Biostatistics

Saturday, February 25, 2017

The Straits Times Friday, May 27 2011

Online Clinical Trial A Success


The next big clinical trial in Singapore could be conducted online.

Scientists from the National University Health System (NUHS) have successfully used a website to conduct a trial. They said this method could save time and help scientists track disease patterns during pandemics.

The results of the trial and the method were published in an online edition of medical journal The Lancet earlier this month.

The scientists set up a website during the H1N1 flu pandemic in 2009 and recruited 1,500 patients from Singapore to test a possible anti-flu drug.

Applicants filled out a questionnaire about their illness on the website. Those who qualified for the trial were screened by doctors in real life.

Selected patients were given drugs and taught to monitor their symptoms and record them through the website.

A hotline was provided for questions and in case the patients had adverse reactions to the drugs.

The scientists said they recruited 1,500 patients in three months, less than half the time needed in similar trials in the past.

"A website can check and disqualify far more people than a doctor can at any time," said Dr Gerard Wong, deputy director of the NUHS investigational medicine unit.

Dr Sophia Archuleta, 38, a consultant in the NUHS division of infectious diseases, said the method could help doctors gather information during virus outbreaks.

"If we can track the disease patterns, we can prevent the next outbreak," she said. "But doctors are usually too busy trying to cure people to collect data."

Dr Wong, 51, added that going online can net a wider range of patients from around the world. "For long-term studies, the patients can come to Singapore to get the drugs and go back to their home countries. We can monitor them online."

But the team noted that the online medium meant applicants are skewed towards the younger, more Internet-savvy generation. In the H1N1 trial, 80 per cent of the patients were aged between 18 and 34. "We can mitigate this by having more print advertisements for other trials," Dr Wong said. He added that the bias is likely to lessen as more generations become computer-literate.

Another limitation of the method is that it cannot be used for trials that involve complicated procedures or intensive treatment. Trials that require patients to spend time in the intensive care unit, for example, cannot be monitored online.

The scientists said such customised websites are costly and suitable only for large-scale trials involving hundreds or thousands of patients. Dr Wong said: "If there are only a few patients, seeing a doctor would be faster and cheaper."

But he noted that most drugs have to go through clinical trials that involve at least hundreds of patients before they can be sold on the market. "Using a website would cut down on the cost and time spent on these trials," he said.

The team's research was funded by the National Medical Research Council and endorsed by an anonymous international review panel as part of the process.

The drug, chloroquine, was found to be ineffective against the H1N1 flu strain.

This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Page 1 of 2


Our New Home

Centre for Translational Medicine

Clinical Trials Pre-screening

The IMU conducts a variety of clinical trials that requires the participation of healthy volunteers and/or individuals with specific medical conditions such as diabetes, high blood pressure etc. If you would like to participate in our clinical trials, please contact Mr Lin Yuchen.

Our Services

Contact Info

Investigational Medicine Unit
National University Health System
Centre for Translational Medicine
NUS Yong Loo Lin School of Medicine
14 Medical Drive, #07-01
Singapore 117599

(Please use Lifts 1,2 or 3 at Fire Fighting Lobby)

NUHS Investigational Medicine Unit

Located at the epicentre of research talent and facilities, the NUHS investigational Medicine Unit is ideally sited for efficient translational of bench discoveries to advanced therapeutics.